ADJECTIVE BODY PART disease ( LETTER FIRST BODY PART STARTS WITH D; fill this in as ___D!) has a prevalence of NUMBER in adults in the United PLURAL NOUN and costs an estimated NUMBER dollars in health NOUN annually. Presentation of this condition includes a wide-ranging constellation of symptoms such as lower ADJECTIVE function and progressively declining NOUN, especially in individuals that may have been exposed to PLURAL NOUN or have a history of ADVERB VERB ENDING IN ING. The combination of these influences, along with potential underlying genetic predisposition, leads to an ADJECTIVE burden that, over time, is thought to contribute to the NOUN of ___D.
Presently, there is ADJECTIVE understanding of the genetic NOUN to this condition, although small cohort PLURAL NOUN have provided some insight. It remains unknown whether development and progression of this complex trait is under regulatory influence of multiple genetic PLURAL NOUN, but publicly available data sets may enable ADJECTIVE and more powerful analyses that will yield actionable information for health care providers, as well as family, caregivers, and PLURAL NOUN of individuals suffering from ___D.
The Multifarious Advanced Disease - Learning Advancement Blueprint (MAD-LAB) cohort was established in YEAR and includes a total of NUMBER adults within NUMBER countries, profiled longitudinally for ten UNIT OF TIME. Whole- NOUN sequencing was performed at baseline, along with annual transcriptomic, metabolomic, and NOUN-omic profiling at each timepoint, and participants were tracked over time for development of ___D, as well as a host of other comorbidities. The MAD-LAB data set presents the unique opportunity to VERB the association between ___D and many potential ADJECTIVE contributors, signs, and symptoms.
The present approach is designed to identify potential single- NOUN polymorphisms that may be at least ADVERB associated with incidence or prevalence of ___D, leading the way for future PLURAL NOUN to establish directionality, causation, or a mechanistic link that may foster future treatment approaches in precision medicine. The hypothesis of this noun is to establish whether there is an association between molecular PLURAL NOUN and prevalent ____D in the MAD-LAB cohort. We will test this hypothesis using the following specific PLURAL NOUN.
Specific Aim 1: Establish single-nucleotide PLURAL NOUN associated with frequency of ___D.
Approach: MAD-LAB genotypes will be undergo cleaning and quality control to identify missingness, as well as excessive NOUN and heterozygosity. Linkage disequilibrium will be used to verb the number of calls to identify kinship and relatedness across PLURAL NOUN.
Expected Outcome: We will identify variants that are associated with prevalent ___D.
Specific Aim 2: Establish relationship between severity of ___D (based on phenotypic scoring of top symptoms) and transcriptomic profiling over disease progression window available in the MAD-LAB cohort.
Approach: Weighted gene correlation analysis will be used to build modules of highly correlated gene expression in individuals with ___D. Phenotypic traits, including mass, years of VERB ENDING IN ING, and whole BODY PART function, will be coded and correlated against resultant modules.
Expected Outcome: We will identify associations of genes related to the severity of key symptoms in ___D.
